Pharmacological properties
Dicloran plus has a local anesthetic, anti-inflammatory and decongestant effect.
Pharmacological action of Dicloran Plus is due to its components. Diclofenac and methyl salicylate are NSAIDs, the anti-inflammatory effect of which is based on the ability to inhibit the synthesis of prostaglandins and thus reduce the severity of symptoms of inflammation.
The main component of flaxseed oil is ?-linolenic acid (ethyl ester of unsaturated fatty acid), which has an anti-inflammatory effect.
Menthol irritates the nerve endings, so it has a local distracting and mild analgesic effect.
Dicloran Plus reduces the severity of pain and inflammation in the joints, morning stiffness and swelling of the joints, increases the range of motion.
When used in the form of a gel, diclofenac and methyl salicylate (3-5% of the dose applied to the skin) are slowly absorbed into the skin, penetrating into the subcutaneous tissue, muscle tissue, joint capsule and articular cavity. With prolonged use or when applied to large areas of the lesion, the components of the preparation gradually penetrate into the subcutaneous tissues, synovial fluid, and blood plasma. Diclofenac is metabolized in the liver by conjugation with glucuronic acid. It is excreted in the urine about 65%, in the feces - 35%.
Indications
Symptomatic treatment of pain, inflammation and swelling in:
damage to soft tissues: injuries to tendons, ligaments, muscles and joints (for example, due to dislocation, sprains, bruises); sports injuries;
inflammatory and degenerative diseases of the joints (osteoarthritis of the peripheral joints and spine), inflammatory lesions of the musculoskeletal system of various origins (bursitis, arthritis, tendosynovitis, tendinitis).
Application
Apply externally!
For adults and children over the age of 12, apply 2–4 g of gel (4–8 cm strip) with a thin layer on the skin and rub it in easily 2-3 times a day. The average daily dose is 10 g of gel, which corresponds to 100 mg of sodium diclofenac. The preparation should be applied to intact skin, avoid contact with eyes and mucous membranes. Do not apply gel to open wounds.
After applying the preparation, you need to wash your hands, except for those cases when this particular area is subject to treatment. The duration of therapy is determined by the doctor depending on the nature of the disease and the effectiveness of the treatment.
The preparation should not be used for more than 14 days in a row - for soft tissue lesions or inflammatory soft tissue diseases, or for more than 21 days for pain caused by arthritis, unless otherwise prescribed by a doctor.
Elderly patients do not need dose adjustment.
Dicloran Plus gel can be used as an additional preparation in patients with joint diseases who are simultaneously taking oral dosage forms of diclofenac sodium.
Contraindications
Hypersensitivity to diclofenac, acetylsalicylic acid and other NSAIDs; hypersensitivity to other components of the preparation; ba, urticaria or rhinitis triggered by the use of acetylsalicylic acid or other NSAIDs; peptic ulcer of the stomach and duodenum in the acute phase; damage to the epidermis, open wounds in the area of ??application.
Side effects
Infections and invasions: pustular eruptions.
From the immune system: hypersensitivity reactions (including urticaria), angioedema.
From the respiratory system: asthma, shortness of breath.
On the part of the skin and connective tissues: rash, including generalized skin rash, itching, eczema, erythema, vesicles, papules, peeling, dermatitis, including contact dermatitis, bullous dermatitis, photosensitivity reactions, skin burning, irritation, skin edema in the place of application of the preparation.
The likelihood of systemic adverse reactions after topical application of diclofenac is small compared to the frequency of adverse reactions during its oral administration, however, if the gel is applied to large areas of the skin for a long time, the possibility of systemic adverse reactions cannot be excluded. In this case, you should be guided by the information provided in the instructions for use for other forms of diclofenac release.
The patient should be informed about the need to stop using the preparation and consult a doctor in case of any side effects or other unusual reactions.
Special instructions
Use only as an external agent. use with caution with oral NSAIDs. since the likelihood of developing systemic side effects with topical application of diclofenac is not excluded when applied to fairly large areas of the skin in high doses or for a long time, the preparation should be used with caution in case of gastric ulcer and duodenal ulcer in the acute stage and in history, liver dysfunction / kidneys, hematopoiesis disorder, polyposis of the nasal mucosa.
The preparation is recommended to be applied only to intact skin areas, avoiding contact with inflamed, damaged or infected skin.
Avoid getting the preparation in the eyes and on the mucous membranes of other organs. The preparation should not be swallowed.
The preparation contains propylene glycol, which may cause mild localized skin irritation in some patients.
If any skin rash appears, treatment should be discontinued. Do not apply under an airtight occlusive dressing. In the event of a sprain, the affected area can be tied with a bandage.
Application during pregnancy or lactation. In the I and II trimester of pregnancy, the preparation should be used only if absolutely necessary in small areas for a short time. In the third trimester of pregnancy, the use of the preparation is contraindicated due to the effect of diclofenac or other prostaglandin inhibitors on the possibility of premature closure of the ductus arteriosus or the absence of uterine contractions.
There is no experience of using the preparation during breastfeeding, therefore, breastfeeding should be stopped for the period of treatment.
If there is a good reason for using the preparation during lactation, when the expected benefit of the preparation outweighs the potential risk, the gel should not be applied to the mammary glands or large areas of the skin and should not be used for a long time.
The ability to influence the reaction rate when driving or working with other mechanisms. There are no reports of the effect on the ability to drive vehicles with topical application of diclofenac.
Children. There is insufficient data on the efficacy and safety of the preparation in children under the age of 12, therefore the preparation is contraindicated in children of this age.
If this medication is needed for pain relief for more than 7 days, or if symptoms increase, the patient / parents are advised to see a doctor.
Interactions
Diclofenac can potentiate the action of preparations that induce photosensitization.
There have been no reports of clinically significant interactions with other preparations. However, it should be borne in mind that diclofenac sodium can potentiate specific effects, in particular the ulcerogenic effect of GCS, increase the concentration of lithium in the blood, and weaken the effect of diuretics and saluretics of the thiazide and furosemide groups. With simultaneous use with anticoagulants, the state of the blood coagulation system should be monitored.
Care should be taken with the simultaneous use of a gel with NSAIDs for oral administration, since there is a risk of mutual potentiation of toxic effects, especially systemic side effects.
Overdose
A very low level of systemic absorption of the active components of the preparation when applied externally makes an overdose almost impossible.
In case of accidental ingestion, treatment is the same as for NSAID poisoning. The patient should see a doctor. Symptomatic treatment is carried out when signs of complications such as high blood pressure, renal failure, convulsions, respiratory depression, complications from the digestive tract appear.
Storage conditions
At a temperature not exceeding 30 ° c. do not freeze.
